5 Ancient Remedies for Cold Sores That Still Work

The herpes simplex virus type 1 (HSV-1), the primary cause of cold sores, has ancient origins dating back about 5,000 years.

Research suggests that the virus spread widely during the Bronze Age, coinciding with cultural practices such as romantic kissing, making cold sores a condition known since prehistoric times.

Throughout history, various cultures have relied on natural remedies to soothe and heal cold sores.

Many of these treatments have been passed down through generations and remain popular today due to their effectiveness and gentle properties.

Here are five ancient remedies for cold sores that have stood the test of time and continue to offer relief.

1. Lemon Balm (Melissa officinalis)

Lemon balm has been used medicinally for over 2,000 years, with records from ancient Greece and Rome praising its healing properties.

The Greek physician Dioscorides documented lemon balm’s use in soothing wounds and viral infections, and it was cultivated in medieval monastic gardens as a valued herb.

Its antiviral and anti-inflammatory compounds help reduce the severity and duration of cold sore outbreaks.

Applying lemon balm extract or cream directly to the affected area can soothe irritation and promote faster healing.

Modern research supports lemon balm’s ability to inhibit HSV-1 replication, confirming its longstanding reputation as an effective natural treatment.

2. Licorice Root (Glycyrrhiza glabra)

Licorice root has a rich history in traditional medicine dating back thousands of years, used in ancient Egypt, China, and Greece.

Its active compounds, such as glycyrrhizic acid, have demonstrated antiviral and immune-boosting effects against herpes viruses.

Topical preparations made from licorice root have been used to reduce inflammation and accelerate healing of cold sores.

Its inclusion in ointments and creams across cultures highlights its enduring role as a soothing and effective remedy.

3. Aloe Vera

Aloe vera’s use as a healing plant dates back to ancient Egypt, where it was called the “plant of immortality” and used for skin conditions and wounds.

Its gel contains compounds that reduce pain, inflammation, and promote tissue repair, making it ideal for cold sore relief. Applying pure aloe vera gel to cold sores can soothe discomfort and support healing.

Its gentle moisturizing properties make it suitable for sensitive skin prone to outbreaks, a use that has persisted through centuries of herbal medicine traditions worldwide.

4. Calendula (Calendula officinalis)

Calendula, or marigold, has been used for centuries in European and Mediterranean herbal medicine to treat wounds and skin inflammation.

Ancient herbal texts describe its antimicrobial and anti-inflammatory properties, which help reduce redness and swelling.

Topical calendula creams or ointments applied to cold sores stimulate skin regeneration and promote faster recovery.

Its longstanding use in traditional remedies underscores its value as a natural healing agent.

5. Honey

Honey has been prized since ancient times for its medicinal qualities, including antibacterial and antiviral effects.

Ancient civilizations such as the Egyptians, Greeks, and Romans used honey to treat wounds and infections, benefiting from its soothing and protective properties. Applying raw or medical-grade honey to cold sores helps keep the area moist, prevents infection, and speeds healing.

Honey’s ability to inhibit viral growth and promote skin repair has made it a trusted remedy across millennia, continuing to be recommended in modern natural medicine.